Proteasomal inhibition effects Notch signaling (937.2)
نویسندگان
چکیده
منابع مشابه
The effects of proteasomal inhibition on synaptic proteostasis
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-proteasome system (UPS) affects the degradation rates of thousands of neuronal and synaptic proteins. W...
متن کاملInhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses
Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and...
متن کاملLateral inhibition of Notch signaling in neoplastic cells
During normal development, heterogeneous expression of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral inhibition. It is unclear if an analogous phenomenon occurs in malignant cells. We observed significant induction of Notch ligands in glioblastoma neurospheres and pancreatic carcinoma cells cultured in low oxygen, suggesting that this phe...
متن کاملInhibition of IκB kinase in Notch signaling activates FOXO3a
The notch signaling pathway is highly conserved and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of notch signaling results in excessive cellular proliferation and a wide range of malignan-cies. However, notch can also act as a tumor suppressor, and its inactivation has been associated with an increased risk of spont...
متن کاملInhibition of Notch signaling pathway attenuates sympathetic hyperinnervation
21 Background: Inflammation-dominated sympathetic sprouting adjacent to the necrotic 22 region following myocardial infarction (MI) has been implicated in the etiology of 23 arrhythmias resulting in sudden cardiac death; however, the mechanisms responsible remain 24 to be elucidated. Although being a key immune mediator, the role of the Notch has yet to be 25 explored. 26 Objective: We investig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.937.2